Developmental origin and lineage plasticity of endogenous cardiac stem cells

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Developmental origin and lineage plasticity of endogenous cardiac stem cells.

Over the past two decades, several populations of cardiac stem cells have been described in the adult mammalian heart. For the most part, however, their lineage origins and in vivo functions remain largely unexplored. This Review summarizes what is known about different populations of embryonic and adult cardiac stem cells, including KIT(+), PDGFRα(+), ISL1(+)and SCA1(+)cells, side population c...

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In the past few years it has been established that the heart contains a reservoir of stem and progenitor cells. These cells are positive for various stem/progenitor cell markers (Kit, Sca-1, Isl-1, and Side Population (SP) properties). The relationship between the various cardiac stem cells (CSC) and progenitor cells described awaits clarification. Furthermore, they may open a new therapeutic s...

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ژورنال

عنوان ژورنال: Development

سال: 2016

ISSN: 1477-9129,0950-1991

DOI: 10.1242/dev.111591